James Edward Metherall, Ph.D., MBA

Department of Human Genetics
Program in Human Molecular Biology
and Genetics Eccles Institute of Human Genetics
Building 533, Room 3410
University of Utah Salt Lake City, Utah 84112
Tel: (801) 585-5345
FAX: (801) 585-3501
E-mail: metherall@NOSPAM.genetics.utah.edu

Date of Birth:                    August 23, 1959
Home Address:                 2225 South Lakeline Drive
                                         Salt Lake City, Utah 84109

1993-1997    M.B.A. David Eccles School of Business, University of Utah
1981-1986    Ph.D. Human Genetics, Yale University
1977-1981    B.A. Chemistry, University of Vermont

1992-             Assistant Professor, Department of Human Genetics, The Program in Human Molecular Biology and Genetics, University of Utah
                          Project: Intracellular Cholesterol Transport
1987-1992     Post-Doctoral Fellow, Department of Molecular Genetics, University of Texas Southwestern Medical Center
                          Project: Somatic Cell Genetics of Cholesterol Homeostasis
                          Advisors: Michael S. Brown, M.D. and Joseph L. Goldstein, M.D.
1981-1986     Doctoral Candidate, Department of Human Genetics, Yale University
                          Project: Molecular Characterization of Non-deletion Hereditary Persistence of Fetal Hemoglobin
                          Advisor: Francis Collins, M.D.,Ph.D. and Bernard G. Forget, M.D.
1979-1981     Undergraduate Research Fellow, Department of Biochemistry, University of Vermont
                          Project: Organic Synthesis of Thioesters for Trials as Chemotherapeutic Agents
                          Advisor: Michael Strauss, Ph.D. Project: Structural Studies of Ovotransferrin Advisor: Robert C. Woodworth, Ph.D.
1977-1979      Research Fellow, Alaska Pipeline Project: United States Army Corps of Engineers, Cold Regions Research Laboratory  
                          Project: Tensile Strength of Frozen Soil Samples to Determine Placement of Pipeline Footings Project: Conditions for Pouring Concrete at Subzero Temperatures
                          Advisor: Frank Sayles, Ph.D.

1994-              Director of University of Utah cDNA Library Core Facility
1993               The California Tobacco-related Disease Research Program (ad hoc reviewer)
1992-              The Journal of Biological Chemistry (ad hoc reviewer) 1992- Molecular and Cellular Biology (ad hoc reviewer)
1992-              The Journal of Lipid Research (ad hoc reviewer)
1991-1992      Instructor, Graduate Program in Cell and Molecular Biology, Southwestern Graduate School, University of Texas
1983-1986      Computer Consultant, Clinical Genetics Service, Yale University School of Medicine
1981-1983      Teaching Assistant, Human Genetics for Medical Students, Yale University School of Medicine

1995-1998       Elected Member University of Utah Academic Senate
1993-1998       Established Investigator of the American Heart Association
1993-1994       John Roland Anderson Scholar, David Eccles School of Business, University of Utah
1993-               Elected Fellow of the American Heart Association
1993-               Elected Member of the American Society for Biochemistry and Molecular Biology
1978-1981       Travelli Scholar, University of Vermont

1996-               Faculty Advisor- Medical Scientist Training Program
1996-1998       Semester Conversion Committee - Molecular Biology Combined Program
1996-               Medical Center Faculty Advisor- University Parking Committee
1996                 Faculty Representative- Medical Education Reaccreditation Site Visit
1996-               Faculty Advisor- The Information Technology Group
1996-               Faculty Advisor- Imaging Core Facility
1995-1996       Committee on Governance and Administration, School of Medicine
1995-               Track Director- Genome Sciences Training Grant
1995                Department of Human Genetics Faculty Search Committee
1994-               Faculty Advisor- DNA Sequencing Core Facility
1994-1997       Department of Human Genetics Graduate Student Committee
1994-1995       Department of Human Genetics Promotions and Retention's Committee

1994                 Molecular Cloning and Expression of Biololically-Active Diptheria Toxin Receptor. Eidels, L., Naglich, J. and Metherall, J. E. (Patent Number: 5,366,874; Issued: Nov. 22, 1994).

Michael S. Brown, M.D. and Joseph L. Goldstein, M.D.
Department of Molecular Genetics University of Texas Southwestern Medical Center
5323 Harry Hines Boulevard Dallas, Texas 75235
Tel: (214) 688-2179

Francis S. Collins, M.D., Ph.D.
Director, National Center for Human Genome Research
National Institutes of Health- PHS,DHHS
Bethesda, Maryland 20892

DeBry, P., Nash, E. A., Neklason, D., Metherall, J. E. (1997) Role of Multidrug Resistance (MDR) P-Glycoproteins in Cholesterol Esterification J. Biol. Chem. 272, (in press).

Jackson, S. M., Ericsson, J., Goto, A., Metherall, J. E., and Edwards, P. A. (1996) Sterol Regulatory Element Binding Protein is Involved in the Regulation of Farnesyl Diphosphate Synthase and Chyolesterol and Fatty Acid Synthesis: Evidence from Sterol Regulation-Defective Cell Lines. J. Lipid Research 37, 1712-1721.

Metherall, J. E., Waugh, K., Li, H. (1996) Progesterone Inhibits Cholesterol Biosynthesis: Accumulation of Sterol Precursors J. Biol. Chem. 271, 2627-2633.

Metherall, J. E., Li, H., Waugh, K. (1996) Role of Multidrug Resistance (MDR) P-Glycoproteins in Cholesterol Biosynthesis. J. Biol. Chem. 271, 2634-2640.

Evans, M. J., Metherall, J. E. (1993) Loss of Transcriptional Repression of Three Sterol-regulated Genes in Mutant Hamster Cell Lines. Mol. Cell. Biol. 13, 5175-5185.

Naglich, J., Metherall, J. E., Russell, D. W., Eidels, L. (1992) Expression Cloning of a Diphtheria Toxin Receptor : Identity with a Heparin-Binding EGF-Like Growth Factor Precursor. Cell 69, 1051-1061.

Metherall, J. E., Ridgway, N. D., Dawson, P. A., Goldstein, J. L., Brown, M. S. (1991) A 25-Hydroxycholesterol Resistant Cell Line Deficient in Acyl CoA:Cholesterol Acyltransferase J. Biol. Chem. 266, 12734-12740.

Dawson, P. A., Metherall, J. E., Ridgway, N. D., Brown, M. S., Goldstein, J. L. (1991) Separation of Transcriptional and Post-transcriptional Regulation of 3-hydroxy-3-methylglutaryl Coenzyme A Reductase in Mutant Hamster Cells. J. Biol.Chem. 266, 9128-9134.

Metherall, J. E., Goldstein, J. L., Luskey, K. L., Brown, M. S. (1989) Loss of Transcriptional Repression of Three Sterol-regulated Genes in Mutant Hamster Cell Lines. J. Biol. Chem. 264, 15634-15641.

Glazer, P. M., Greggio, N. A., Metherall, J. E., Summers, W. C. (1989) UV-induced DNA-binding Proteins in Human Cells. Proc. Natl. Acad. Sci. 86, 1163-1167.

Metherall, J. E., Gillespie, F. P. and Forget, B.G. (1988) Analysis of Linked *- Globin Genes Suggests that Non-deletion forms of Hereditary Persistence of Fetal Hemoglobin are bona fide Switching Mutants. Am. J. of Human Genetics 42, 476-481.

Stoeckert, C. J., Metherall, J. E., Yamakawa. M., Forget, B. G., Eisenstadt, J. M. and Weissman, S. M. (1987) Elevated Expression of a Greek Hereditary Persistence of Fetal Hemoglobin A* Gene in a Human Erythroid Cell Line. Mol. Cell. Bio. 7, 2999-3003.

Metherall, J. E., Collins, F. S., Pan, J., Weissman, S. M. and Forget, B. G. (1986) *0 Thalassemia Caused by a Base Substitution that Creates an Alternate Splice Acceptor Site. EMBO J. 5, 2551-2557.

Collins, F. S., Metherall, J. E., Yamakawa, M., Pan, J., Weissman, S. M. and Forget, B. G. (1985) A Point Mutation in the A*-Globin Gene Promoter in Greek Hereditary Persistence of Fetal Hemoglobin. Nature 313, 325-326.

Metherall, J. E., Gillespie, F. P. and Forget, B.G. (1989) Nuclear Proteins of a Human Erythroleukemic Cell Line That Bind to the Promoter Region of Normal and Nondeletion HPFH *-Globin Genes. Prog. in Clin. & Biol. Res. 316A, 247-260.

Metherall, J. E., Stoeckert, C. J., Gillespie, F. P., Weissman, S. M. and Forget, B.G. (1987) Support for the Causal Relationship Between *-globin Gene Promoter Mutations and Non-deletion Forms of Hereditary Persistence of Fetal Hemoglobin. Prog. Clin. Biol. Res. 251, 347-361.

Forget, B. G., Feingold, E. A. and Metherall, J. E. (1987) Molecular Genetics of Deletion and Nondeletion Forms of Hereditary Persistence of Fetal Hemoglobin. In Molecular Biology in Hematology. pp. 149-154. Prof. F. Coronia ed. Associazione Talassemici Siciliani, Polermo, Italy.

DiMaio, D., Metherall, J. E., Neary, K. and Guralski, D. (1986) Genetic Analysis of Cell Transformation by Bovine Papillomavirus. In Papillomaviruses: Clinical and Molecular Aspects. F. Fox ed. U.C.L.A. Symp. Mol. Cell. Bio. 32, 437-456.

Forget, B. G., Feingold, E. A., Metherall, J. E. and Collins, F. S. (1986) Hemoglobin Switching. In The Role of Recombinant DNA in Genetics. R. L. Teplitz and D. Loukopoulos eds.

Feingold, E. A., Collins, F. S., Metherall, J. E., Stoeckert, C. J., Weissman, S. M. and Forget, B. G. (1985) Molecular Analysis of Deletion and Non-deletion Hereditary Persistence of Fetal Hemoglobin and Identification of a New Mutation Causing *-Thalassemia. Ann. N.Y. Acad. Sci. 445, 159-169.

Feingold, E. A., Collins, F. S., Metherall, J. E., Stoeckert, C. J., Weissman, S. M. and Forget, B. G. (1985) Analysis of Mutations Associated with Deletion and Non-deletion Hereditary Persistence of Fetal Hemoglobin. In Experimental Approaches for the Study of Hemoglobin Switching. pp. 107-124 G. Stamatoyannopoloulos and A. W. Nienhuis eds. Alan R. Liss, Inc. New York.

Ardehali, R., Topaz, S., Metherall, J. E., Burns, G. L., Mohammad, S. F. (1996) Effect of Shear Stress on Cell Attachment to Polyurethane. American Society for Artificial Internal Organs. May 2-4, Washington, D.C.

Metherall, J. E., Nash, E., Neklason, D., Coulter, K. (1995) The Role of MDR in Cholesterol Metabolism. Aspen Bile Acid and Lipid Conference, Aspen, Colorado.

Metherall, J. E., Nash, E., Neklason, D. W., Mykytyn, K. (1995) Role of MDR P-Glycoproteins in Cellular Cholesterol Metabolsim and Coronary Heart Disease. Gordon Research Conference on Lipid Metabolism. Kimbal Union Academy, Meriden, New Hampshire.

Ardehali, R., Metherall, J. E., Topaz, S., Burns, G. L., Mohammad, S. F. (1995) Expression Cloning Approach to Enhance Endothelial Cell Attachment to Polyurethane. American Society for Artificial Internal Organs. Chicago, Illinois.

DeBry, P., Metherall, J. E. (1994) P-Glycoprotein Functions in Intracellular Sterol Transport. National Medical Student Research Forum. Galveston, Texas.

DeBry, P., Metherall, J. E. (1993) P-Glycoprotein Functions in Intracellular Sterol Transport. American Federation of Clinical Research / Western Medical Student Research Forum. Carmel, California.

Carter, T., Metherall, J. E. (1993) Biochemical Characterization of Acyl CoA:Cholesterol Acyltransferase. 7th National Conference on Undergraduate Research. Salt Lake City, Utah.

Naglich, J., Metherall, J. E., Eidels, L. (1992) Expression Cloning of the Diphtheria Toxin Receptor. Joint Meeting of 1992 ASBMB / Biophysical Society. Houston, Texas.

Metherall, J. E., Ridgway, N. D., Dawson, P. A., Goldstein, J. L., Brown, M. S. (1991) A 25-Hydroxycholesterol Resistant Cell Line Deficient in Acyl CoA:Cholesterol Acyltransferase American Heart Association Annual Meeting. Dallas, Texas.

Forget, B. G., Feingold, E. A. and Metherall, J. E. (1987) Molecular Genetics of Deletion and Nondeletion Forms of Hereditary Persistence of Fetal Hemoglobin. European Hematology Society. Polermo, Italy.

Metherall, J. E., Stoeckert, C. J., Gillespie, F. P., Weissman, S. M. and Forget, B.G. (1987) Support for the Causal Relationship Between *-globin Gene Promoter Mutations and Non-deletion Forms of Hereditary Persistence of Fetal Hemoglobin. Red Cell Conference. Airlie House, Virginia.

Feingold, E. A., Collins, F. S., Metherall, J. E., Stoeckert, C. J., Weissman, S. M. and Forget, B. G. (1985) Molecular Analysis of Deletion and Non-deletion Hereditary Persistence of Fetal Hemoglobin and Identification of a New Mutation Causing *-Thalassemia. Annual Meeting of the New York Academy of Sciences. New York, New York.