Research Papers (Last Updated 3/03)

Scuderi, A., Simin, K., Metherall, J.E., Letsou, A. (2003)  
scylla and charybde Encode Redundant Functions Essential for 
Drosophila Embryonic Development (submitted).

Davies, B.S.J., Metherall, J.E. (2003) 
High Prevalence of 7-Dehydrocholesterol Reductase Mutations in the Normal Population and 
Patieints with Coronary Heart Disease. (in press).

Hoshijima, K., Metherall, J.E., Grunwald, D.J. (2003)  
A Protein Disulfide Isomerase Expressed in the Embryonic Midline 
is Required for Left/Right Asymmetries. 
Genes and Development 16, 2518-2529. [Abstract, PDF]

Simin, K., Scuderi, A., Reamey, J., Weiss, R., Metherall, J.E., Letsou, A.  (2002) 
Profiling Patterned Transcripts in Drosophila Embryos. 
Genome Research 12, 1040-1047. [Abstract, PDF]
(see commentary: Oliver, B. (2002) Fly Factory. Genome Research 12, 1017-1018.) [PDF]

Gao, Z. H., Metherall, J.E., Virshup, D. M.  (1999) 
Identification of Casein Kinase I Substrates by in vitro Expression Cloning (IVEC) Screening. 
Biochem. Biophys. Res. Com. 268, 562-566. [Abstract]

Elsea, S. H., Mykytyn, K., Ferrell, K., Das, P., Dubiel, W., Patel, P. I., Metherall, J. E.  (1999) 
The COP9 signalosome subunit gene, SGN3, maps with in the Smith-Magenis syndrome critical interval. 
Am. J. Med. Gen. 87, 342-348. [Abstract, PDF]

Neklason, D. W., Kelley, R., Metherall, J. E. (1999) 
Biochemical Variants of 7-Dehydrocholesterol Reductase Deficiency. 
Am. J. Med. Genetics 85, 517-523 [Abstract, PDF]

DeBry, P., Nash, E. A., Neklason, D., Metherall, J. E. (1997)  
Role of Multidrug Resistance (MDR) P-Glycoproteins in Cholesterol Esterification 
J. Biol. Chem. 272, 1026-1031 [Abstract, PDF]

Jackson, S. M., Ericsson, J., Goto, A., Metherall, J. E., and Edwards, P. A. (1996)  
Sterol Regulatory Element Binding Protein is Involved in the Regulation of Farnesyl Diphosphate Synthase 
and Cholesterol and Fatty Acid Synthesis: Evidence from Sterol Regulation-Defective Cell Lines. 
J. Lipid Research 37, 1712-1721 [Abstract, PDF]

Metherall, J. E., Waugh, K., Li, H. (1996) 
Progesterone Inhibits Cholesterol Biosynthesis: Accumulation of Sterol Precursors 
J. Biol. Chem. 271, 2627-2633 [Abstract, PDF]

Metherall, J. E., Li, H., Waugh, K. (1996)  
Role of Multidrug Resistance (MDR) P-Glycoproteins in Cholesterol Biosynthesis.  
J. Biol. Chem. 271, 2634-2640 [Abstract, PDF]

Evans, M. J., Metherall, J. E.  (1993)  
Loss of Transcriptional Repression of Three Sterol regulated Genes in Mutant Hamster Cell Lines. 
Mol. Cell. Biol. 13, 5175-5185 [Abstract]

Naglich, J., Metherall, J. E., Russell, D. W., Eidels, L. (1992)  
Expression Cloning of a Diphtheria Toxin Receptor : Identity with a Heparin-Binding EGF-Like 
Growth Factor Precursor.  
Cell  69, 1051-1061. [Abstract]

Metherall, J. E., Ridgway, N. D., Dawson, P. A., Goldstein, J. L., Brown, M. S. (1991)  
A 25-Hydroxycholesterol Resistant Cell Line Deficient in Acyl CoA:Cholesterol Acyltransferase  
J. Biol. Chem. 266, 12734-12740. [Abstract, PDF]

Dawson, P. A., Metherall, J. E., Ridgway, N. D., Brown, M. S., Goldstein, J. L. (1991)  
Separation of Transcriptional and Post transcriptional Regulation of 3 hydroxy 3 methylglutaryl 
Coenzyme A Reductase in Mutant Hamster Cells. 
J. Biol.Chem. 266, 9128-9134. [Abstract, PDF]

Metherall, J. E., Goldstein, J. L., Luskey, K. L., Brown, M. S. (1989)  
Loss of Transcriptional Repression of Three Sterol regulated Genes in Mutant Hamster Cell Lines.  
J. Biol. Chem.  264, 15634 15641. [Abstract, PDF]

Glazer, P. M., Greggio, N. A., Metherall, J. E., Summers, W. C. (1989) 
UV induced DNA binding Proteins in Human Cells. 
Proc. Natl. Acad. Sci. 86, 1163 1167. [Abstract]

Metherall, J. E., Gillespie, F. P. and Forget, B.G. (1988)  
Analysis of Linked *- Globin Genes Suggests that Non deletion forms of Hereditary Persistence of 
Fetal Hemoglobin are bona fide Switching Mutants. 
Am. J. of Human Genetics  42, 476 481. [Abstract]

Stoeckert, C. J., Metherall, J. E., Yamakawa. M., Forget, B. G., Eisenstadt, J. M. and Weissman, S. M. (1987)  
Elevated Expression of a Greek Hereditary Persistence of Fetal Hemoglobin A* Gene in a Human Erythroid Cell Line. 
Mol. Cell. Bio. 7, 2999 3003. [Abstract]

Metherall, J. E., Collins, F.S., Pan, J., Weissman, S. M. and Forget, B. G. (1986)  
*0 Thalassemia Caused by a Base Substitution that Creates an Alternate Splice Acceptor Site. 
EMBO J. 5, 2551 2557. [Abstract]

Collins, F. S., Metherall, J. E., Yamakawa, M., Pan, J., Weissman, S. M. and Forget, B. G. (1985)  
A Point Mutation in the A*-Globin Gene Promoter in Greek Hereditary Persistence of Fetal Hemoglobin. 
Nature 313, 325 326. [Abstract]